Organoid Electrophysiology
Intra-organoid penetrating probes with Radiens signal quality, archive triage, and signed data provenance. Built for academic labs now. Architected for pharma throughput next.
Brain organoids are the fastest-growing model system in neuroscience — three-dimensional neural tissues grown from human stem cells, capable of spontaneous electrical activity, network formation, and responses to pharmacological agents. The electrophysiology tools haven't kept up. We're building them.
Why NeuroNexus
Probe Expertise
210+ silicon-probe designs and 22 years of fabrication experience. We know how to build interfaces for neural tissue — including tissue that grows in a dish.
Vertical Integration
We manufacture the electrodes and build the software. Organoid-specific probe geometries paired with Radiens acquisition and analysis from day one.
Active Collaborations
Co-developing with leading organoid research labs. Our approach is driven by real experimental needs, not speculative product roadmaps.
Radiens Platform
Per-well signal quality and analysis across batches — the same platform behind our in vivo workflows.
Collaboration-Driven Development
Organoid electrophysiology is a young field with unique challenges — three-dimensional tissue geometry, long-term culture stability, multi-organoid experiments, and the need to track maturation over weeks or months.We're not building in isolation. Our organoid initiative is co-developed with leading research labs, ensuring that every design decision is grounded in real experimental workflows. The goal is purpose-built hardware and software that works from the first recording session.
3D Tissue Geometry
Electrode designs optimized for three-dimensional organoid structures, not adapted from planar in vivo probes.
Long-Term Monitoring
Chronic recording capabilities for tracking organoid maturation over weeks to months.
Multi-Well Compatibility
Scalable configurations for high-throughput organoid experiments and pharmacological screening.
What We're Building
Our organoid electrophysiology initiative is in active development — purpose-built hardware and optimized Radiens workflows designed together from the ground up.
Flexible and rigid electrode configurations designed specifically for 3D organoid tissue — surface arrays, penetrating probes, and multi-well formats.
Radiens modules for tracking organoid development through electrophysiological markers: spike rates, burst patterns, network synchrony, and connectivity metrics.
Radiens workflows for organoid lineage tracking, differentiation protocols, developmental staging, and longitudinal comparison across batches.
We're actively partnering with leading organoid research groups to validate designs, refine workflows, and ensure that what we build works in real experiments. If your lab is pushing the boundaries of organoid electrophysiology, we'd like to hear from you.
Powered by Radiens
Organoid workflows run on the same Radiens platform that powers our in vivo recording solutions. One environment for acquisition, signal quality, analysis, and provenance.Lite is free and perpetual. Pro adds cloud sorting and domain analytics. Whether you record from rodent cortex or a cultured organoid, the software adapts to the preparation.
Signal Quality Intelligence
Per-well SNR and impedance during acquisition. Sessions below threshold flagged before offline analysis.
Archive Triage (on the roadmap)
On the roadmap: find the wells worth analyzing before running ICA on 24 of them.
Data Certification (on the roadmap)
On the roadmap: data certification — dataset provenance, carried further.
For Drug Screening and Discovery
The organoid platform is architected for pharma throughput from v1 — decision-grade quantitative endpoints (firing rate, burst metrics, spectral power, cross-organoid synchrony) with published reliability data and a throughput path from academic-scale to 96-well automation.
Validated quantitative readouts with published reliability. Reference-compound dose-response libraries in development.
v1 at 8–24 wells, v1.5 at 24–96 wells, v2 full 96-well automation. Well geometry, probe indexing, DAQ multiplexing designed for scale from day one.
On the roadmap: data certification — dataset provenance carried further, for audit-ready trust without the compliance overhead.
Organoid Electrophysiology — FAQ
Can I record from brain organoids with NeuroNexus hardware today?
Multi-electrode arrays for 3-D organoid and in-vitro recording are in the catalog; a purpose-built organoid platform is in development.
How is organoid recording different from in-vivo probes?
3-D tissue needs arrays that interface across the organoid volume, with chronic protocols for maturation tracking rather than acute insertion.
What software analyzes organoid electrophysiology data?
Radiens handles spike sorting, burst metrics, spectral power, and cross-organoid synchrony from the same acquisition runtime.